096 Transcriptomic analysis of epidermal barrier molecules, cytokines and growth factors in atopic dermatitis lesions
نویسندگان
چکیده
منابع مشابه
Epidermal Barrier in Atopic Dermatitis
Atopic dermatitis (AD) is a complex disease that affects up to 20% of children and impacts the quality of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Filaggrin (FLG) is synthesized as a large precursor, profilaggrin, and is expressed in the u...
متن کاملEpidermal Barrier Dysfunction: Beyond Atopic Dermatitis
of the epidermal barrier has expanded greatly over the course of the last two decades. Primary functions of the epidermal barrier are to protect against the entry of foreign substances (antigens, irritants, and microbes). In addition to these primarily defensive roles, the epidermis traps moisture and regulates hydration, and it synthesizes vitamin D. The epidermal barrier is not a passive stru...
متن کاملThe Role of Impaired Epidermal Barrier Function in Atopic Dermatitis.
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease with increasing prevalence. The etiopathogenesis of atopic dermatitis is multifactorial and involves a complex interplay of environmental and genetic factors that induce derangements in the structure and function of the epidermal barrier and immune system. Due to great heterogeneity of etiopathogenesis, there is also great...
متن کاملTh2 Cytokines and Atopic Dermatitis.
Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in prevalence around the world. Intensive research is ongoing to understand the mechanisms involved in the development of AD and offer new treatment options for patients suffering from AD. In this review, we highlight the importance of allergic Th2 responses in the development of the disease and summarize relev...
متن کاملSkin barrier in atopic dermatitis.
The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in particular atopic dermatitis (AD). This review ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.06.114